MyBioSource.com's FKBP6 Rabbit mAb is a Rabbit monoclonal antibody. The FKBP6 Rabbit mAb Antibody was generated using FKBP prolyl isomerase family member 6 (inactive), and FKBP6 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Western Blot.
Description
Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity)